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  1. Treatment Options for People with HER2-Mutant Non-Small Cell Lung ...

    Jul 8, 2024 · ENHERTU then enters the cancer cell and chemotherapy is released, helping destroy the cancer cell, as well as other cells nearby. “The FDA approval of ENHERTU for …

  2. Non-Small Cell Lung Cancer Patients Harboring HER2 Mutations: …

    Mutation of human receptor tyrosine kinase epidermal growth factor receptor-2 (HER2) is a rare event, found in approximately 1% non-small cell lung cancers (NSCLC). The objective was to …

  3. HER2 in Non-Small Cell Lung Cancer: A Review of Emerging …

    Aug 27, 2022 · Abstract Human epidermal growth factor receptor 2 (HER2), a member of the ERBB family of tyrosine kinase receptors, has emerged as a therapeutic target of interest for …

  4. Management of HER2 alterations in non-small cell lung cancer

    Abstract HER2 mutations, which account for 2-4% of non-small cell lung cancer (NSCLC), are distinct molecular alterations identified via next generation sequencing (NGS). Previously, …

  5. The Year in Cancer Research: 2025 Breakthroughs and What’s …

    6 days ago · Sevabertinib made waves this year as a targeted therapy for non-small cell lung cancer with HER2 mutations. Until recently, these patients had limited treatment options after …

  6. Lung Cancer in Young Adults: What Loryn’s Stage 4 HER2+ Lung Cancer ...

    In November 2024, I was diagnosed with stage 4 non-small cell lung cancer with a HER2 mutation. My friends would probably describe me as very loyal, consistent, and reliable.

  7. HER2 Mutation & metastatic Non-Small Cell Lung Cancer

    Currently, HER2 (ERBB2) is identified as an actionable biomarker by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). 1 Mutations in HER2 (ERBB2) have similar …

  8. Record History | ver. 6: 2025-11-25 - ClinicalTrials.gov

    This study is open to adults 18 years and older who have early-stage non-small cell lung cancer (NSCLC). Their cancer must have a specific change in a gene called HER2. Genes provide …

  9. Clinical outcomes and characterization of HER2 alterations in Non Small ...

    Jun 4, 2025 · Background Subsets of NSCLC carry alterations in the human epidermal growth factor receptor 2 (HER2) gene such as mutations (mt), amplification (amp), and protein …

  10. Study Details | BIPI Medical & Clinical Resources

    This study is open to adults 18 years and older who have early-stage non-small cell lung cancer (NSCLC). Their cancer must have a specific change in a gene called HER2.